Calcium supplements can lower risk of advanced colon polyps

Related tags Colorectal cancer Cancer

Calcium supplements, previously shown to cut the risk of colorectal
polyps, appears to have the greatest effect on advanced colorectal
adenomas, considered to be most strongly associated to invasive
colorectal cancer, according to a multi-centre study.

"Our results suggest that calcium supplementation may have a more protective effect on advanced adenomas than on other types of colorectal polyps,"​ said Kristin Wallace, a graduate student from US-based Dartmouth Medical School and lead author on the study. "These findings highlight the need to consider 'polyp type' when assessing the efficacy of a given treatment."

Colorectal polyps, or adenomas, are bumps or fleshy tumours that occur on the inside lining of the colon that may become cancerous over time. By decreasing the size of the polyps and their number, there is less potential for colorectal cancer.

The study, reported in today's issue of the Journal of the National Cancer Institute​ (vol 96, no 12, pp 921-925), builds on prior research and provides more evidence that calcium supplementation appears to be a relatively safe and inexpensive way to reduce the risk of the most serious types of colorectal polyps.

Cancer of the colon or rectum is the second deadliest form of cancer after lung cancer but is also considered one of the most preventable types of cancer, as there are several dietary factors that appear to play a protective role against the disease.

"Previous studies have demonstrated an association between calcium intake and moderate decreases in the risk of precancerous colorectal tumours, but this is the first randomised trial to evaluate the effect of calcium on different types of colorectal lesions,"​ added project leader John Baron, professor of medicine and of community and family medicine at Dartmouth and an investigator at Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center.

Researchers analysed data from 913 patients enrolled in the Calcium Polyp Prevention Study, a randomized, double-blind trial. Patients took either a 1200 mg calcium supplement or a placebo and had a follow-up colonoscopy one and four years after enrolling in the trial.

The results showed that supplemental calcium slightly decreased the risk of all types of colorectal polyps, but effect was greatest for the most advanced colorectal lesions. There was also some evidence that a diet high in fibre and low in fat increased the preventive effect of calcium, but these results were not statistically definitive.

Related topics Ingredients

Related products

show more

Dairy proteins now available from Univar Solutions

Dairy proteins now available from Univar Solutions

Content provided by Univar Solutions | 20-Sep-2023 | White Paper

Foodology by Univar Solutions proudly partners with Leprino Nutrition as their North American distributor of nutritional ingredients and dairy products.

Clean Label Ingredients for Shelf-Life Extension

Clean Label Ingredients for Shelf-Life Extension

Content provided by Lesaffre | 19-Sep-2023 | White Paper

Product waste skyrockets without anti-staling agents and mold inhibitors. But consumers are scrutinizing labels more than ever before. How can you have...

Sustainability Claims Impact on Consumer Purchases

Sustainability Claims Impact on Consumer Purchases

Content provided by ADM | 07-Sep-2023 | Insight Guide

Discover what consumers say about sustainability claims versus what they do in the grocery aisle. Find out in this can’t-miss proprietary study from ADM:...

Cost-effective & efficient: Angel Prebake Solution

Cost-effective & efficient: Angel Prebake Solution

Content provided by Angel Yeast – Yeast and Baking Ingredients | 31-Jul-2023 | White Paper

After years of systematic research and practical application in the production process and essential ingredients for frozen dough, Angel's pre-bake...

Related suppliers

Follow us


View more