Tackling obesity at the protein level

- Last updated on GMT

Related tags: Imperial college london, Obesity

Scientists have discovered a protein that controls the amount of
fat stored in the body, offering potential new clues for obesity
treatments - welcome news as the world's health leaders agree to do
more to tackle the growing problem.

The research, published in this week's Proceedings of the National Academy of Sciences​, shows how the protein regulates the activity of a key gene responsible for maintaining the body's temperature, called uncoupling protein 1 (UCP1).

The new protein, called RIP140, blocks the expression of UCP1, and causes the body to use up more energy and store less fat.

The team of British scientists from Imperial College London, Kings College London, University of Cambridge, and Hammersmith Hospital conducted studies in transgenic mice born without RIP140, and in normal mice with RIP140. They found that mice without RIP140 were lean and showed resistance to high fat diet induced obesity.

On average, mice without RIP140 were 20 per cent lighter compared with normal mice and accumulated between 50 and 70 per cent less fat when compared with mice with RIP140, even though their food intake was similar.

Professor Malcolm Parker from Imperial College London, one of the study's authors, said that the discovery could prove vital in the growing war against obesity. "By reducing the levels of RIP140, it is possible to increase the activity of the UCP1 gene. UCP1 plays a key role in regulating energy balance in the body, and through this we can reduce body weight by increasing energy expenditure.

"Although these are very promising observations we do need to be careful in interpreting the results. The study was carried out in mice, which were born without RIP140, and it will be important to determine the consequences of blocking RIP140 action in adult animals."

This work was supported by the Wellcome Trust and the Biotechnology and Biological Sciences Research Council. Professor Parker and his team have recently signed a deal with CytRx, a US based biopharmaceutical company, to commercialise the results of the research.

Related topics: Ingredients

Related news

Related products

show more

We offer even more reason to indulge.

We offer even more reason to indulge.

ADM | 22-Sep-2022 | Insight Guide

Consumers want snacks that are both delicious and nutritious. That’s why we incorporate more fiber and plant-based choices and use ingredients like botanical...

Food ingredients from Cambridge Commodities

Food ingredients from Cambridge Commodities

Cambridge Commodities | 01-Sep-2022 | Product Brochure

At Cambridge Commodities, we supply a variety of food ingredients for inclusion in bakery products, cereal, snacks, bars and more. We can also offer bespoke...

Bakery Boom: Reinvention invites smart indulgence

Bakery Boom: Reinvention invites smart indulgence

Cargill | 23-Aug-2022 | Technical / White Paper

While bakery products may be the ultimate comfort food, concerns about sugar and carbohydrate content have led many consumers to feel torn about their...

Related suppliers

Follow us

Products

View more

Webinars